Further improvements in aero-engine efficiencies require accurate prediction of flow physics and incurred loss. Currently, the computational requirements for capturing these are not known leading to inconsistent loss predictions even for scale-resolving simulations depending on the chosen convergence criteria. This work investigates two aspects of loss generation using high-fidelity simulation. In the first case study, we look at the effect of resolution on capturing entropy generation rate by simulating a Taylor-Green vortex canonical flow. The second case study focuses on the effect of resolution on flow physics and loss generation and uses a compressor cascade subjected to freestream turbulence. The results show that both resolving local entropy generation rate and capturing the inception and growth of instabilities are critical to accuracy of loss prediction. In particular, the interaction of free-stream turbulence at the leading-edge and development of instabilities in the laminar region of the boundary layer are critical to capturing loss.