This paper reports on a parametric investigation of the thermal enhancement of a double-reflector parabolic trough collector when employing an in-line mixed V-shape (IMVS) ribbed absorber tube. Three heat transfer fluids (HTFs) are investigated, and a wide range of fluid inlet temperatures are studied. Various geometric parameters of the V-shape rib are analyzed to determine the optimum design of such a modification to the wall of the absorber tube. Results show that the HTF thermal oil Syltherm 800 is superior to the other HTFs that were studied. Results also show that a lower inlet temperature of the HTF leads to better thermo-hydraulic performance. The study provides a set of values for designing a V-shape ribbed absorber tube that produces optimum thermo-hydraulic performance. The optimum ribbed tube design shows a performance enhancement of about 64% compared to a smooth tube.