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Jeffrey W. Holmes
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Proceedings Papers

Isotonic Biaxial Loading: An Economic, Versatile Method for the Study of Fibroblast-Populated Collagen Gels

Jeffrey W. Holmes, Thomas K. Borg
Proc. ASME. IMECE99, Advances in Bioengineering, 111-112, November 14–19, 1999
Publisher: American Society of Mechanical Engineers
Paper No: IMECE1999-0402
https://doi.org/10.1115/IMECE1999-0402
View Paper titled, Isotonic Biaxial Loading: An Economic, Versatile Method for the Study of Fibroblast-Populated Collagen Gels
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Topics: Economics , Fibroblasts, Stress, Biological tissues, Biology, Manganese (Metal)
Proceedings Papers

A Matlab-Based Cardiac Mechanics Course: Exportable Tools for Graduate-Level Soft Tissue Biomechanics

Jeffrey W. Holmes
Proc. ASME. IMECE2001, Advances in Bioengineering, 43, November 11–16, 2001
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2001/BED-23021
https://doi.org/10.1115/IMECE2001/BED-23021
View Paper titled, A Matlab-Based Cardiac Mechanics Course: Exportable Tools for Graduate-Level Soft Tissue Biomechanics
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Topics: Matlab, Musculoskeletal soft tissue mechanics, Students, Bridges (Structures), Computer programming, Elasticity, Engineering simulation, Simulation
Journal Articles

Longitudinal Reinforcement of Acute Myocardial Infarcts Improves Function by Transmurally Redistributing Stretch and Stress

Ana Cristina Estrada, Kyoko Yoshida, Samantha A. Clarke, Jeffrey W. Holmes
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2020, 142(2): 021009.
Paper No: BIO-18-1444
https://doi.org/10.1115/1.4044030
Published Online: October 11, 2019
View Article titled, Longitudinal Reinforcement of Acute Myocardial Infarcts Improves Function by Transmurally Redistributing Stretch and Stress
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Topics: Fibers, Finite element model, Myocardium, Pressure, Stress, Materials properties
Journal Articles

Open-Source Routines for Building Personalized Left Ventricular Models From Cardiac Magnetic Resonance Imaging Data

Thien-Khoi N. Phung, Christopher D. Waters, Jeffrey W. Holmes
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. February 2020, 142(2): 024504.
Paper No: BIO-18-1548
https://doi.org/10.1115/1.4043876
Published Online: October 11, 2019
View Article titled, Open-Source Routines for Building Personalized Left Ventricular Models From Cardiac Magnetic Resonance Imaging Data
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Topics: Finite element analysis, Geometry, Magnetic resonance imaging, Imaging
Journal Articles

The Impact of Hemodynamic Reflex Compensation Following Myocardial Infarction on Subsequent Ventricular Remodeling

Colleen M. Witzenburg, Jeffrey W. Holmes
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. September 2019, 141(9): 091010.
Paper No: BIO-19-1091
https://doi.org/10.1115/1.4043867
Published Online: August 2, 2019
View Article titled, The Impact of Hemodynamic Reflex Compensation Following Myocardial Infarction on Subsequent Ventricular Remodeling
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Topics: Hemodynamics, Pressure, Myocardium, Blood
Journal Articles

Model First and Ask Questions Later: Confessions of a Reformed Experimentalist

Jeffrey W. Holmes
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Expert View
J Biomech Eng. July 2019, 141(7): 074701.
Paper No: BIO-18-1282
https://doi.org/10.1115/1.4043432
Published Online: May 23, 2019
View Article titled, Model First and Ask Questions Later: Confessions of a Reformed Experimentalist
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Topics: Biological tissues, Biomechanics, Design, Fibers, Modeling, Testing, Collaboration, Cartilage, Engineering teachers, Computer simulation
Journal Articles

Special Issue: Spotlight on the Future of Cardiovascular Engineering: Frontiers and Challenges in Cardiovascular Biomechanics

Jeffrey W. Holmes, Jessica E. Wagenseil
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Guest Editorial
J Biomech Eng. November 2016, 138(11): 110301.
Paper No: BIO-16-1388
https://doi.org/10.1115/1.4034873
Published Online: October 21, 2016
View Article titled, Special Issue: Spotlight on the Future of Cardiovascular Engineering: Frontiers and Challenges in Cardiovascular Biomechanics
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Topics: Biological tissues, Biomechanics, Cardiovascular system, Modeling
Proceedings Papers

Fiber-Based Constitutive Model of Myocardial Scar Tissue

Dezba G. Coughlin, Gregory M. Fomovsky, Jeffrey W. Holmes
Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 157-158, June 20–24, 2007
Publisher: American Society of Mechanical Engineers
Paper No: SBC2007-176098
https://doi.org/10.1115/SBC2007-176098
View Paper titled, Fiber-Based Constitutive Model of Myocardial Scar Tissue
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Topics: Biological tissues, Constitutive equations, Fibers, Structural analysis
Proceedings Papers

Evolution of Scar Mechanical Properties During Myocardial Infarct Healing in Rat

Gregory M. Fomovsky, Jeffrey W. Holmes
Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 197-198, June 20–24, 2007
Publisher: American Society of Mechanical Engineers
Paper No: SBC2007-176422
https://doi.org/10.1115/SBC2007-176422
View Paper titled, Evolution of Scar Mechanical Properties During Myocardial Infarct Healing in Rat
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Topics: Anisotropy, Mechanical properties
Proceedings Papers

Structural Mechanism for Alteration of Collagen Gel Mechanics by Glutaraldehyde Crosslinking

Preethi L. Chandran, Dezba G. Coughlin, David C. Paik, Jeffrey W. Holmes
Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 209-210, June 20–24, 2007
Publisher: American Society of Mechanical Engineers
Paper No: SBC2007-176462
https://doi.org/10.1115/SBC2007-176462
View Paper titled, Structural Mechanism for Alteration of Collagen Gel Mechanics by Glutaraldehyde Crosslinking
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Topics: Anisotropy, Biological tissues, Density, Kinematics, Mechanical properties, Microscale devices, Modeling, Valves
Proceedings Papers

Finite Element Simulations of Left Atrial Filling Following Radiofrequency Ablation

Christian B. Moyer, Patrick T. Norton, John D. Ferguson, Jeffrey W. Holmes
Proc. ASME. FMD2013, ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation, V001T05A001, September 11–13, 2013
Publisher: American Society of Mechanical Engineers
Paper No: FMD2013-16029
https://doi.org/10.1115/FMD2013-16029
View Paper titled, Finite Element Simulations of Left Atrial Filling Following Radiofrequency Ablation
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Topics: Ablation (Vaporization technology), Arrhythmias, Biological tissues, Drugs, Engineering simulation, Failure, Finite element analysis, Finite element model, Muscle, Patient treatment
Proceedings Papers

Do Infarcts Really Expand or Compact? Relationship Between Changing Material Properties and Apparent Infarct Remodeling

William J. Richardson, Jeffrey W. Holmes
Proc. ASME. SBC2013, Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments, V01AT11A001, June 26–29, 2013
Publisher: American Society of Mechanical Engineers
Paper No: SBC2013-14411
https://doi.org/10.1115/SBC2013-14411
View Paper titled, Do Infarcts Really Expand or Compact? Relationship Between Changing Material Properties and Apparent Infarct Remodeling
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Topics: Biological tissues, Heart failure, Materials properties, Muscle, Myocardium, Risk, Stress
Proceedings Papers

Collagen Fiber Structure Correlates With Mechanical Environment in Healing Myocardial Infarcts

Gregory M. Fomovsky, Jeffrey W. Holmes
Proc. ASME. SBC2009, ASME 2009 Summer Bioengineering Conference, Parts A and B, 415-416, June 17–21, 2009
Publisher: American Society of Mechanical Engineers
Paper No: SBC2009-206767
https://doi.org/10.1115/SBC2009-206767
View Paper titled, Collagen Fiber Structure Correlates With Mechanical Environment in Healing Myocardial Infarcts
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Topics: Fibers, Anisotropy, Mechanical properties
Proceedings Papers

Development of Anisotropy in Fibroblast Populated Collagen Gels

Stavros Thomopoulos, Vedran Knezevic, Kevin D. Costa, Jeffrey W. Holmes
Proc. ASME. IMECE2002, Advances in Bioengineering, 253-254, November 17–22, 2002
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2002-32781
https://doi.org/10.1115/IMECE2002-32781
View Paper titled, Development of Anisotropy in Fibroblast Populated Collagen Gels
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Topics: Anisotropy, Fibroblasts, Biological tissues, Stress, Bearings, Boundary-value problems, Mechanical properties, Muscle, Soft tissues, Tendons
Proceedings Papers

A Structural Basis for Anisotropy in Cardiac Fibroblast Populated Collagen Gels

Stavros Thomopoulos, Jeffrey W. Holmes
Proc. ASME. IMECE2004, Advances in Bioengineering, 305-306, November 13–19, 2004
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2004-61209
https://doi.org/10.1115/IMECE2004-61209
View Paper titled, A Structural Basis for Anisotropy in Cardiac Fibroblast Populated Collagen Gels
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Topics: Anisotropy, Fibroblasts, Fibers, Biological tissues, Mechanical properties, Bearings, Soft tissues, Stress
Journal Articles

Collagen Fiber Alignment Does Not Explain Mechanical Anisotropy in Fibroblast Populated Collagen Gels

Stavros Thomopoulos, Gregory M. Fomovsky, Preethi L. Chandran, Jeffrey W. Holmes
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. October 2007, 129(5): 642–650.
https://doi.org/10.1115/1.2768104
Published Online: February 15, 2007
View Article titled, Collagen Fiber Alignment Does Not Explain Mechanical Anisotropy in Fibroblast Populated Collagen Gels
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Topics: Anisotropy, Fibers, Network models, Fibroblasts, Stress, Mechanical testing, Biological tissues, Deformation
Journal Articles

The Development of Structural and Mechanical Anisotropy in Fibroblast Populated Collagen Gels

Stavros Thomopoulos, Gregory M. Fomovsky, Jeffrey W. Holmes
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. October 2005, 127(5): 742–750.
https://doi.org/10.1115/1.1992525
Published Online: May 19, 2005
View Article titled, The Development of Structural and Mechanical Anisotropy in Fibroblast Populated Collagen Gels
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Topics: Anisotropy, Fibers, Fibroblasts, Biological tissues, Mechanical testing, Tendons, Mechanical properties
Journal Articles

Determinants of Left Ventricular Shape Change During Filling

Jeffrey W. Holmes, M.D., Ph.D.
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. February 2004, 126(1): 98–103.
https://doi.org/10.1115/1.1645527
Published Online: March 9, 2004
View Article titled, Determinants of Left Ventricular Shape Change During Filling
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Topics: Fibers, Shapes, Stiffness