Process-induced damage to cells is of significant importance and must be mitigated for safe and reproducible cell direct writing. The objective of this study is to investigate the cell membrane stability under the external normal pressure. This investigation is performed by studying the dipalmitoylphosphatidylcholine bilayer behavior under different normal pressures using molecular dynamics. As the normal pressure increases, the force necessary to rupture the bilayer structure decreases, which indicates cell membrane instability under high normal pressure. This phenomenon can also be explained by the change of free energy difference before and after rupture under different normal pressures. The effect of the pulling speed on the rupture force is also investigated, showing that the rupture force increases almost linearly with the pulling speed.
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e-mail: yongh@clemson.edu
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October 2011
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Study of Process-Induced Cell Membrane Stability in Cell Direct Writing
Jun Yin,
Jun Yin
Department of Mechanical Engineering,
Clemson University
, Clemson, SC 29634
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Yong Huang
Yong Huang
Department of Mechanical Engineering,
e-mail: yongh@clemson.edu
Clemson University
, Clemson, SC 29634
Search for other works by this author on:
Jun Yin
Department of Mechanical Engineering,
Clemson University
, Clemson, SC 29634
Yong Huang
Department of Mechanical Engineering,
Clemson University
, Clemson, SC 29634e-mail: yongh@clemson.edu
J. Manuf. Sci. Eng. Oct 2011, 133(5): 054501 (5 pages)
Published Online: August 30, 2011
Article history
Received:
September 27, 2009
Revised:
July 17, 2011
Online:
August 30, 2011
Published:
August 30, 2011
Citation
Yin, J., and Huang, Y. (August 30, 2011). "Study of Process-Induced Cell Membrane Stability in Cell Direct Writing." ASME. J. Manuf. Sci. Eng. October 2011; 133(5): 054501. https://doi.org/10.1115/1.4004685
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