... in predicting mechanical properties with less than 15% error. We envisage that the developed technique can be used for better estimation of cells' constitutive parameters by incorporating cell topography into account. mechanophenotyping AFM ANN FEM nanoindentation Mechanophenotyping...

...) fluorescent microscopy (FM) atomic force microscopy (AFM) nanoindentation European Research Council 10.13039/501100000781 647067 Aortic smooth muscle cells (SMCs) are known to be very sensitive to their micro-environment. Under physiological conditions, mature SMCs remain quiescent...

... to an implant. Eight coin-shaped Ti6Al4V implants were inserted into rabbit tibiae for 7 and 13 weeks using an in vivo model allowing the distinction between mature and newly formed bone in a standardized configuration. Nanoindentation and micro-Brillouin scattering measurements were carried out in similar...

... the evolution of the hardness and indentation modulus of newly formed bone tissue as a function of healing time. To do so, a nanoindentation device is employed following a multimodality approach using histological analysis. Coin-shaped implants were placed in vivo at a distance of 200 μm from the cortical bone...

... of the subchondral bone. An established nanoindentation method was adopted to determine the modulus of subchondral bone following penetration of the overlying articular cartilage. Three cycles of repeated loadings were applied (2.452 N, 30 s hold). The slope of the load-displacement response during the unloading...

...D. Carnelli; D. Gastaldi; V. Sassi; R. Contro; C. Ortiz; P. Vena A finite element model was developed for numerical simulations of nanoindentation tests on cortical bone. The model allows for anisotropic elastic and post-yield behavior of the tissue. The material model for the post-yield behavior...

... of bone matrix, can also contribute in controlling its viscoelastic property. Nanoindentation viscosity was used as a direct measure for the capacity of a material to resist viscous-like flow under loading. The objectives of this study were to examine (1) whether the nanoindentation viscosity obtained...

...Giampaolo Franzoso; Philippe K. Zysset The identification of anisotropic elastic properties of lamellar bone based on nanoindentation data is an open problem. Therefore, the purpose of this study was to develop a method to estimate the orthotropic elastic constants of human cortical bone secondary...

...Gang Huang; Nitin P. Daphalapurkar; Rong Z. Gan; Hongbing Lu A viscoelastic nanoindentation technique was developed to measure both in-plane and through-thickness viscoelastic properties of human tympanic membrane (TM). For measurement of in-plane Young’s relaxation modulus, the TM sample...