... results in more drug droplets reaching the lungs rather than being wasted in the oral cavity, pharynx, and larynx, as is the case with traditional inhalers [ 16 , 17 ]. Despite substantial research on drug delivery to the human respiratory tract for treating asthma and chronic obstructive pulmonary...

...Jason N. Mehta; Brianna E. Morales; Fang-Chi Hsu; John H. Rossmeisl; Christopher G. Rylander Convection-enhanced delivery (CED) has been extensively studied for drug delivery to the brain due to its inherent ability to bypass the blood-brain barrier. Unfortunately, CED has also been shown...

... of in vivo tissues. Such FEMs will provide basic understanding of normal and pathological tissue responses and lead to optimization of local drug delivery strategies. We present a coupled porohyperelastic mass transport (PHEXPT) finite element approach developed using a commercially available ABAQUS finite...

...R. A. Guha; N. H. Shear; M. Papini The impact and penetration of high speed particles with the human skin is of interest for targeted drug delivery by transdermal powder injection. However, it is often difficult to perform penetration experiments on dermal tissue using micron scale particles...

... distributions following CED into the spinal cord. Quantification of these transport fields provides an important step toward development of drug-specific transport models of infusion. biological tissues biomedical MRI biotransport brain drug delivery systems neurophysiology convection-enhanced...

... pump out cytotoxic drugs from the intracellular space. In this study, we tested a hypothesis that freezing and thawing (F/T) may enhance intracellular drug delivery to MDR cancer cells via F/T-induced denaturation of MDR-associated proteins and/or membrane permeabilization. After a human MDR cancer...

... for the development of computational tools, e.g., for the optimization of intrathecal drug delivery and computer-aided evaluation of cerebral pathologies such as syrinx development in syringomelia. Davson , H. , Welch , K. , Segal , M. B. , and Davson , H. , 1987 , Physiology...

...Frank E. Fresconi; Ajay K. Prasad The adverse health effects of inhaled particulate matter from the environment depend on its dispersion, transport, and deposition in the human airways. Similarly, precise targeting of deposition sites by pulmonary drug delivery systems also relies on characterizing...

... drug delivery systems haemodynamics physiological models polymer films drug eluting stents drug delivery diffusion therapeutic window restenosis Drug eluting stents (DESs) are coated with drugs that inhibit smooth muscle cells and myofibroblasts replication and neointima growth...

... pneumodynamics toxicology respiratory airway bifurcation lung flow secondary velocity aerosol transport dispersion drug delivery Medical applications such as the administration of anesthesia, alternative modes of ventilation (such as high-frequency ventilation (HFV) ( 1 )), and clinical...