...Cameron A. Czerpak; Yik Tung Tracy Ling; Joan L. Jefferys; Harry A. Quigley; Thao D. Nguyen The lamina cribrosa (LC) is a connective tissue in the optic nerve head (ONH). The objective of this study was to measure the curvature and collagen microstructure of the human LC, compare the effects...

... pathological development in the cells; pathological or aging cells, on the other hand, can alter their micro-environment to become abnormal. In this minireview, we discuss four important biophysical cues of the micro-environment—stiffness, curvature, extracellular matrix (ECM) architecture and viscosity...

... artery with physiologically relevant flow parameters. To study the effect of coronary artery (CA) geometry change on stent elastic modulus mismatch, models where the curvature, torsion and both curvature and torsion change were examined. The elastic modulus is increased by a factor of two, five, and ten...

...Kathleen D. Klinich; Sheila M. Ebert; Matthew P. Reed Knowledge of the distributions of cervical-spine curvature is needed for computational studies of cervical-spine injury in motor-vehicle crashes. Many methods of specifying spinal curvature have been proposed, but they often involve qualitative...

... is not extensively studied. In this work, we focus our investigation on the localized hemodynamic effects of dynamic changes in curvature and torsion. It is our objective to understand and reveal the mechanism by which changes in curvature and torsion contribute towards the observed wall shear stress distribution...

... typically depicted and used, our mean artery was tortuous exhibiting nonplanarity and complex curvature and torsion variations. The bifurcation angle was 36 deg ± 11 deg if measured using arterial centerlines and 15 deg ± 14 deg if measured between the walls of the carotid bifurcation branches. The average...

.... 12 08 2011 21 11 2011 21 12 2011 21 12 2011 adhesion blood vessels flow simulation haemodynamics shear flow shear stress curvature venule arteriole computational discrete element model Tortuous blood vessels, including microvessels, are often seen...

... existing CT data, the three-dimensional geometry of nine unruptured human AAAs was reconstructed and characterized quantitatively. We propose and evaluate a series of 1D size, 2D shape, 3D size, 3D shape, and second-order curvature-based indices to quantify AAA geometry, as well as the geometry of a size...

... in ABAQUS . Effective material fiber orientations were assumed to align with principal surface curvatures. Static deformation of the aneurysm models were simulated assuming uniform wall thickness and internal pressure load of 100 mm Hg . Results. The numerical analysis technique was validated...

... by endothelial cells. These structures are subject to large mechanical deformations when the plasma membrane is stretched and subject to a change of its curvature. To enhance our understanding of plasmalemmal vesicles we need to improve the understanding of the mechanics in regions of high membrane curvatures...