...Daniel Chaparro; Valentina Dargam; Paulina Alvarez; Jay Yeung; Ilyas Saytashev; Jenniffer Bustillo; Archana Loganathan; Jessica Ramella-Roman; Arvind Agarwal; Joshua D. Hutcheson Understanding aortic valve (AV) mechanics is crucial in elucidating both the mechanisms that drive the manifestation...

...Clara Seaman; A. George Akingba; Philippe Sucosky References [1] Roberts , W. C. , 1970 , “ The Congenitally Bicuspid Aortic Valve. A Study of 85 Autopsy Cases ,” Am. J. Cardiol. , 26 ( 1 ), pp. 72 – 83 . 10.1016/0002-9149(70)90761-7 [2] Sabet , H. Y. , Edwards , W. D...

...Afshin Anssari-Benam; Himadri S. Gupta; Hazel R. C. Screen The complex structural organization of the aortic valve (AV) extracellular matrix (ECM) enables large and highly nonlinear tissue level deformations. The collagen and elastin (elastic) fibers within the ECM form an interconnected fibrous...

...C. Marchand; F. Heim; B. Durand Percutaneous aortic valve implantation has become an alternative technique to surgical valve replacement in patients with high risk for surgery. This technique is at its beginning and stents used for valve prostheses remain standard vascular stents. These stents...

...Choon-Hwai Yap; Lakshmi P. Dasi; Ajit P. Yoganathan Aortic valve (AV) stenosis, if untreated, leads to heart failure. From a mechanics standpoint, heart failure can be interpreted as the failure of the heart to generate sufficient power to overcome energy losses in the circulation. Thus, energy...

...James N. Warnock; Suchitra Konduri; Zhaoming He; Ajit P. Yoganathan The biological response of valves to mechanical forces is not well understood. The aim of this study was to design a pulsatile system to enable the ex vivo study of aortic valves when subjected to various hemodynamic conditions...

... of Approach: A one-dimensional (1-D) FOV reduced relaxation function was developed, replacing the QLV “box-spectrum” function with a fractional relaxation function. A direct-fit, global optimization method was used to estimate material parameters from stress relaxation tests on aortic valve tissue. Results...