A wireless medical capsule for measuring the contact pressure between a mobile capsule and the small intestine lumen was developed. Two pressure sensors were used to measure and differentiate the contact pressure and the small intestine intraluminal pressure. After in vitro tests of the capsule, it was surgically placed and tested in the proximal small intestine of a pig model. The capsule successfully gathered and transmitted the pressure data to a receiver outside the body. The measured pressure signals in the animal test were analyzed in the time and frequency domains, and a mathematic model was presented to describe the different factors influencing the contact pressure. A novel signal processing method was applied to isolate the contraction information from the contact pressure. The result shows that the measured contact pressure was 1.08 ± 0.08 kPa, and the small intestine contraction pressure's amplitude and rate were 0.29 ± 0.046 kPa and 12 min−1. Moreover, the amplitudes and rates of pressure from respiration and heartbeat were also estimated. The successful preliminary evaluation of this capsule implies that it could be used in further systematic investigation of small intestine contact pressure on a mobile capsule-shaped bolus.
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Design of a Wireless Medical Capsule for Measuring the Contact Pressure Between a Capsule and the Small Intestine
Pengbo Li,
Pengbo Li
Mechanical and Material Engineering,
University of Nebraska-Lincoln,
W342 Nebraska Hall,
Lincoln, NE 68588-0526
e-mail: pengbo.li@huskers.unl.edu
University of Nebraska-Lincoln,
W342 Nebraska Hall,
Lincoln, NE 68588-0526
e-mail: pengbo.li@huskers.unl.edu
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Craig Kreikemeier-Bower,
Craig Kreikemeier-Bower
School of Veterinary,
University of Nebraska-Lincoln,
Mussehl Hall 110,
Lincoln, NE 68583
University of Nebraska-Lincoln,
Mussehl Hall 110,
Lincoln, NE 68583
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Wanchuan Xie,
Wanchuan Xie
Mechanical and Material Engineering,
University of Nebraska-Lincoln,
W342 Nebraska Hall,
Lincoln, NE 68588-0526
University of Nebraska-Lincoln,
W342 Nebraska Hall,
Lincoln, NE 68588-0526
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Vishal Kothari,
Vishal Kothari
Department of Surgery,
University of Nebraska Medical Center,
Nebraska Medicine—Bariatrics Center
4400 Emile Street,
Omaha, NE 68198
University of Nebraska Medical Center,
Nebraska Medicine—Bariatrics Center
4400 Emile Street,
Omaha, NE 68198
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Benjamin S. Terry
Benjamin S. Terry
Department of Mechanical and
Materials Engineering,
University of Nebraska-Lincoln,
360 Walter Scott Engineering Center,
Lincoln, NE 68508
Materials Engineering,
University of Nebraska-Lincoln,
360 Walter Scott Engineering Center,
Lincoln, NE 68508
Search for other works by this author on:
Pengbo Li
Mechanical and Material Engineering,
University of Nebraska-Lincoln,
W342 Nebraska Hall,
Lincoln, NE 68588-0526
e-mail: pengbo.li@huskers.unl.edu
University of Nebraska-Lincoln,
W342 Nebraska Hall,
Lincoln, NE 68588-0526
e-mail: pengbo.li@huskers.unl.edu
Craig Kreikemeier-Bower
School of Veterinary,
University of Nebraska-Lincoln,
Mussehl Hall 110,
Lincoln, NE 68583
University of Nebraska-Lincoln,
Mussehl Hall 110,
Lincoln, NE 68583
Wanchuan Xie
Mechanical and Material Engineering,
University of Nebraska-Lincoln,
W342 Nebraska Hall,
Lincoln, NE 68588-0526
University of Nebraska-Lincoln,
W342 Nebraska Hall,
Lincoln, NE 68588-0526
Vishal Kothari
Department of Surgery,
University of Nebraska Medical Center,
Nebraska Medicine—Bariatrics Center
4400 Emile Street,
Omaha, NE 68198
University of Nebraska Medical Center,
Nebraska Medicine—Bariatrics Center
4400 Emile Street,
Omaha, NE 68198
Benjamin S. Terry
Department of Mechanical and
Materials Engineering,
University of Nebraska-Lincoln,
360 Walter Scott Engineering Center,
Lincoln, NE 68508
Materials Engineering,
University of Nebraska-Lincoln,
360 Walter Scott Engineering Center,
Lincoln, NE 68508
Manuscript received November 2, 2016; final manuscript received March 4, 2017; published online March 24, 2017. Assoc. Editor: Nathan Sniadecki.
J Biomech Eng. May 2017, 139(5): 051003 (8 pages)
Published Online: March 24, 2017
Article history
Received:
November 2, 2016
Revised:
March 4, 2017
Citation
Li, P., Kreikemeier-Bower, C., Xie, W., Kothari, V., and Terry, B. S. (March 24, 2017). "Design of a Wireless Medical Capsule for Measuring the Contact Pressure Between a Capsule and the Small Intestine." ASME. J Biomech Eng. May 2017; 139(5): 051003. https://doi.org/10.1115/1.4036260
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