Tissue scaffolds aim to provide a cell-friendly biomechanical environment for facilitating cell growth. Existing studies have shown significant demands for generating a certain level of wall shear stress (WSS) on scaffold microstructural surfaces for promoting cellular response and attachment efficacy. Recently, its role in shear-induced erosion of polymer scaffold has also drawn increasing attention. This paper proposes a bi-directional evolutionary structural optimization (BESO) approach for design of scaffold microstructure in terms of the WSS uniformity criterion, by downgrading highly-stressed solid elements into fluidic elements and/or upgrading lowly-stressed fluidic elements into solid elements. In addition to this, a computational model is presented to simulate shear-induced erosion process. The effective stiffness and permeability of initial and optimized scaffold microstructures are characterized by the finite element based homogenization technique to quantify the variations of mechanical properties of scaffold during erosion. The illustrative examples show that a uniform WSS is achieved within the optimized scaffold microstructures, and their architectural and biomechanical features are maintained for a longer lifetime during shear-induced erosion process. This study provides a mathematical means to the design optimization of cellular biomaterials in terms of the WSS criterion towards controllable shear-induced erosion.
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e-mail: Qing.Li@Sydney.edu.au
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August 2011
Research Papers
Design Optimization of Scaffold Microstructures Using Wall Shear Stress Criterion Towards Regulated Flow-Induced Erosion
Yuhang Chen,
Yuhang Chen
School of Aerospace, Mechanical and Mechatronic Engineering,
The University of Sydney
, Sydney, NSW 2006, Australia
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Michiel Schellekens,
Michiel Schellekens
Department of Mechanical Engineering,
Eindhoven University of Technology
, P.O. Box 513, 5600 MB Eindhoven, The Netherlands
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Shiwei Zhou,
Shiwei Zhou
School of Aerospace, Mechanical and Mechatronic Engineering,
The University of Sydney
, Sydney, NSW 2006, Australia
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Joseph Cadman,
Joseph Cadman
School of Aerospace, Mechanical and Mechatronic Engineering,
The University of Sydney
, Sydney, NSW 2006, Australia
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Wei Li,
Wei Li
School of Aerospace, Mechanical and Mechatronic Engineering,
The University of Sydney
, Sydney, NSW 2006, Australia
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Richard Appleyard,
Richard Appleyard
School of Medicine,
Macquarie University
, NSW 2109, Australia
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Qing Li
Qing Li
Member of ASME, School of Aerospace, Mechanical and Mechatronic Engineering,
e-mail: Qing.Li@Sydney.edu.au
The University of Sydney
, Sydney, NSW 2006, Australia
Search for other works by this author on:
Yuhang Chen
School of Aerospace, Mechanical and Mechatronic Engineering,
The University of Sydney
, Sydney, NSW 2006, Australia
Michiel Schellekens
Department of Mechanical Engineering,
Eindhoven University of Technology
, P.O. Box 513, 5600 MB Eindhoven, The Netherlands
Shiwei Zhou
School of Aerospace, Mechanical and Mechatronic Engineering,
The University of Sydney
, Sydney, NSW 2006, Australia
Joseph Cadman
School of Aerospace, Mechanical and Mechatronic Engineering,
The University of Sydney
, Sydney, NSW 2006, Australia
Wei Li
School of Aerospace, Mechanical and Mechatronic Engineering,
The University of Sydney
, Sydney, NSW 2006, Australia
Richard Appleyard
School of Medicine,
Macquarie University
, NSW 2109, Australia
Qing Li
Member of ASME, School of Aerospace, Mechanical and Mechatronic Engineering,
The University of Sydney
, Sydney, NSW 2006, Australia
e-mail: Qing.Li@Sydney.edu.au
J Biomech Eng. Aug 2011, 133(8): 081008 (10 pages)
Published Online: September 19, 2011
Article history
Received:
April 19, 2011
Revised:
August 18, 2011
Posted:
August 22, 2011
Published:
September 19, 2011
Citation
Chen, Y., Schellekens, M., Zhou, S., Cadman, J., Li, W., Appleyard, R., and Li, Q. (September 19, 2011). "Design Optimization of Scaffold Microstructures Using Wall Shear Stress Criterion Towards Regulated Flow-Induced Erosion." ASME. J Biomech Eng. August 2011; 133(8): 081008. https://doi.org/10.1115/1.4004918
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