Aortic stenosis caused by valve calcification is a major cause of death around the world. Hemodynamic factors have been suggested to be major players in the development of valve calcification, yet a detailed knowledge of the blood flow dynamics as experienced by endothelial cells on valve surfaces is still lacking. In this study we carry out high-resolution numerical simulations of the blood flow through a polymeric trileaflet valve in order to elucidate the differential flow dynamics on the aortic and ventricular sides of the valve leaflets. Limiting streamlines and surface shear stress contours are used to probe and quantify the blood flows on its side. Complicated flow patterns were only observed on the aortic side of the valve near the region where focalized distribution of valve calcification is typically observed.
Issue Section:
Technical Briefs
1.
Otto
, C. M.
, Burwash
, I. G.
, Legget
, M. E.
, Munt
, B. I.
, Fujioka
, M.
, Healy
, N. L.
, Kraft
, C. D.
, Miyake-Hull
, C. Y.
, and Schwaegler
, R. G.
, 1997, “Prospective Study of Asymptomatic Valvular Aortic Stenosis: Clinical, Echocardiographic, and Exercise Predictors of Outcome
,” Circulation
0009-7322, 95
, pp. 2262
–2270
.2.
Pohle
, K.
, Mäffert
, R.
, Ropers
, D.
, Moshage
, W.
, Stilianakis
, N.
, Daniel
, W. G.
, and Achenbach
, S.
, 2001, “Progression of Aortic Valve Calcification Association With Coronary Atherosclerosis and Cardiovascular Risk Factors
,” Circulation
0009-7322, 104
, pp. 1927
–1932
.3.
Agmon
, Y.
, Khandheria
, B. K.
, Meissner
, I.
, Sicks
, J. D.
, O'Fallon
, W. M.
, Wiebers
, D. O.
, Whisnant
, J. P.
, Seward
, J. B.
, and Tajik
, A. J.
, 2001, “Aortic Valve Sclerosis and Aortic Atherosclerosis: Different Manifestations of the Same Disease? Insights From a Population-Based Study
,” J. Am. Coll. Cardiol.
0735-1097, 38
, pp. 827
–834
.4.
Caro
, C. G.
, Fitz-Gerald
, J. M.
, and Schroter
, R. C.
, 1969, “Arterial Wall Shear and Distribution of Early Atheroma in Man
,” Nature (London)
0028-0836, 223
, pp. 1159
–1160
.5.
Caro
, C. G.
, Fitz-Gerald
, J. M.
, and Schroter
, R. C.
, 1971, “Atheroma and Arterial Wall Shear Observation, Correlation and Proposal of a Shear Dependent Mass Transfer Mechanism for Atherogenesis
,” Proc. R. Soc. London, Ser. B
0962-8452, 177
, pp. 109
–133
.6.
Davies
, P. F.
, 1995, “Flow-Mediated Endothelial Mechanotransduction
,” Physiol. Rev.
0031-9333, 75
, pp. 519
–560
.7.
Davies
, P.
, Shi
, C.
, DePaola
, N.
, Helmke
, B.
, and Polacek
, D.
, 2001, “Hemodynamics and the Focal Origin of Atherosclerosis: A Spatial Approach to Endothelial Structure, Gene Expression, and Function
,” Ann. N.Y. Acad. Sci.
0077-8923, 947
, pp. 7
–17
.8.
Davies
, P. F.
, Remuzzi
, A.
, Gordon
, E. J.
, Dewey
, C. F.
, and Gimbrone
, M. A.
, 1986, “Turbulent Fluid Shear Stress Induces Vascular Endothelial Cell Turnover in Vitro
,” Proc. Natl. Acad. Sci. U.S.A.
0027-8424, 83
, pp. 2114
–2117
.9.
Butcher
, J. T.
, and Nerem
, R. M.
, 2007, “Valvular Endothelial Cells and the Mechanoregulation of Valvular Pathology
,” Philos. Trans. R. Soc. London, Ser. B
0962-8436, 362
, pp. 1445
–1457
.10.
Thubrikar
, M. J.
, Aouad
, J.
, and Nolan
, S. P.
, 1986, “Patterns of Calcific Deposits in Operatively Excised Stenotic or Purely Regurgitant Aortic Valves and Their Relation to Mechanical Stress
,” Am. J. Cardiol.
0002-9149, 58
, pp. 304
–8
.11.
Otto
, C.
, Kuusisto
, J.
, Reichenbach
, D.
, Gown
, A.
, and O’Brien
, K.
, 1994, “Characterization of the Early Lesion of ‘Degenerative’ Valvular Aortic Stenosis. Histological and Immunohistochemical Studies
,” Circulation
0009-7322, 90
, pp. 844
–853
.12.
Nicosia
, M. A.
, Cochran
, R. P.
, Einstein
, D. R.
, Rutland
, C. J.
, and Kunzelman
, K. S.
, 2003, “A Coupled Fluid-Structure Finite Element Model of the Aortic Valve and Root
,” J. Heart Valve Dis.
0966-8519, 12
, pp. 781
–9
.13.
Mohler
, E. R.
, III, 2004, “Mechanisms of Aortic Valve Calcification
,” Am. J. Cardiol.
0002-9149, 94
, pp. 1396
–1402
.14.
Haj-Ali
, R.
, Dasi
, L. P.
, Kim
, H.
, Choi
, J.
, Leo
, H.
, and Yoganathan
, A. P.
, 2008, “Structural Simulations of Prosthetic Tri-Leaflet Aortic Heart Valves
,” J. Biomech.
0021-9290, 41
, pp. 1510
–1519
.15.
Ge
, L.
, and Sotiropoulos
, F.
, 2007, “A Numerical Method for Solving the 3D Unsteady Incompressible Navier–Stokes Equations in Curvilinear Domains With Complex Immersed Boundaries
,” J. Comput. Phys.
0021-9991, 225
, pp. 1782
–1809
.16.
Dasi
, L. P.
, Ge
, L.
, Simon
, H. A.
, Sotiropoulos
, F.
, and Yoganathan
, A. P.
, 2007, “Vorticity Dynamics of a Bileaflet Mechanical Heart Valve in an Axisymmetric Aorta
,” Phys. Fluids
1070-6631, 19
, pp. 067105
.17.
Tobak
, M.
, and Peake
, D. J.
, 1982, “Topology of Three-Dimensional Separated Flows
,” Annu. Rev. Fluid Mech.
0066-4189, 14
, pp. 61
–85
.18.
Ethier
, C.
, Prakash
, S.
, Steinman
, D. A.
, Leask
, R. L.
, Couch
, G. G.
, and Ojha
, M.
, 2000, “Steady Flow Separation Patterns in a 45 Degree Junction
,” J. Fluid Mech.
0022-1120, 411
, pp. 1
–38
.19.
Malek
, A. M.
, Alper
, S. L.
, and Izumo
, S.
, 1999, “Hemodynamic Shear Stress and Its Role in Atherosclerosis
,” JAMA, J. Am. Med. Assoc.
0098-7484, 282
, pp. 2035
–2042
.20.
Simmons
, C. A.
, Grant
, G. R.
, Manduchi
, E.
, and Davies
, P. F.
, 2005, “Spatial Heterogeneity of Endothelial Phenotypes Correlates With Side-Specific Vulnerability to Calcification in Normal Porcine Aortic Valves
,” Circulation Research
, 96
, pp. 792
–799
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