This paper presents an analysis of void growth and coalescence in isotropic, elastoplastic materials exhibiting sigmoidal hardening using unit cell calculations and micromechanics-based damage modeling. Axisymmetric finite element unit cell calculations are carried out under tensile loading with constant nominal stress triaxiality conditions. These calculations reveal the characteristic role of material hardening in the evolution of the effective response of the porous solid. The local heterogeneous flow hardening around the void plays an important role, which manifests in the stress–strain response, porosity evolution, void aspect ratio evolution, and the coalescence characteristics that are qualitatively different from those of a conventional power-law hardening porous solid. A homogenization-based damage model based on the micromechanics of void growth and coalescence is presented with two simple, heuristic modifications that account for this effect. The model is calibrated to a small number of unit cell results with initially spherical voids, and its efficacy is demonstrated for a range of porosity fractions, hardening characteristics, and void aspect ratios.