Research Papers: Design for Manufacture and the Life Cycle

Mechanics of Three-Dimensional Printed Lattices for Biomedical Devices

[+] Author and Article Information
Paul F. Egan

Department of Mechanical Engineering,
Texas Tech University,
ME North 201,
Box 41021,
Lubbock, TX 79409 − 1021;
ETH Zurich,
Institute for Biomechanics,
Building HPP,
Honggerbergring 64,
Zurich 8093, Switzerland
e-mails: paul.egan@ttu.edu;

Isabella Bauer

ETH Zurich,
Institute for Biomechanics,
Building HPP,
Honggerbergring 64,
Zurich 8093, Switzerland
e-mail: baueri@student.ethz.ch

Kristina Shea

ETH Zurich,
Department of Mechanical and
Process Engineering,
Building CLA,
Tannenstrasse 3,
Zurich 8092, Switzerland
e-mail: kshea@ethz.ch

Stephen J. Ferguson

ETH Zurich,
Institute for Biomechanics,
Building HPP,
Honggerbergring 64,
Zurich 8093, Switzerland
e-mail: sferguson@ethz.ch

1Corresponding author.

Contributed by the Design for Manufacturing Committee of ASME for publication in the JOURNAL OF MECHANICAL DESIGN. Manuscript received July 1, 2018; final manuscript received December 5, 2018; published online January 14, 2019. Assoc. Editor: Carolyn Seepersad.

J. Mech. Des 141(3), 031703 (Jan 14, 2019) (12 pages) Paper No: MD-18-1529; doi: 10.1115/1.4042213 History: Received July 01, 2018; Revised December 05, 2018

Advances in three-dimensional (3D) printing are enabling the design and fabrication of tailored lattices with high mechanical efficiency. Here, we focus on conducting experiments to mechanically characterize lattice structures to measure properties that inform an integrated design, manufacturing, and experiment framework. Structures are configured as beam-based lattices intended for use in novel spinal cage devices for bone fusion, fabricated with polyjet printing. Polymer lattices with 50% and 70% porosity were fabricated with beam diameters of 0.41.0mm, with measured effective elastic moduli from 28MPa to 213MPa. Effective elastic moduli decreased with higher lattice porosity, increased with larger beam diameters, and were highest for lattices compressed perpendicular to their original build direction. Cages were designed with 50% and 70% lattice porosities and included central voids for increased nutrient transport, reinforced shells for increased stiffness, or both. Cage stiffnesses ranged from 4.1kN/mm to 9.6kN/mm with yielding after 0.360.48mm displacement, thus suggesting their suitability for typical spinal loads of 1.65kN. The 50% porous cage with reinforced shell and central void was particularly favorable, with an 8.4kN/mm stiffness enabling it to potentially function as a stand-alone spinal cage while retaining a large open void for enhanced nutrient transport. Findings support the future development of fully integrated design approaches for 3D printed structures, demonstrated here with a focus on experimentally investigating lattice structures for developing novel biomedical devices.

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Fig. 1

Design, manufacturing, and experiment approach, shown for 3D printed lattices in spinal cage devices

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Fig. 2

Designed lattice samples

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Fig. 3

Support material removal for samples (a) as-printed, (b) after external support removal, (c) in chemical bath, and (d) cleaned (10mm length indicator)

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Fig. 4

Lattice in-plane and out-of-plane compression testing, with indicated build direction (0.5mm scale bars), sample height, and circled region indicating a broken beam from the build/clean process

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Fig. 5

(a) Designed spinal cage devices with varied configuration strategies and (b) schematic indicating labeled faces, build direction, and height h

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Fig. 6

Top and side faces of samples (0.5mm scale bar)

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Fig. 7

Measured beam diameters on (a) top and (b) side faces for porosity P=50% samples and (c) top and (d) side faces for P=70% samples; dotted lines represent ideal match between design and measurement

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Fig. 8

Effective elastic modulus as porosity and beam diameter varies, with linear regression fits

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Fig. 9

Effective elastic modulus for in-plane and out-of-plane compression orientations

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Fig. 10

Effective elastic modulus after two and four weeks in varied conditions for (a) porosity P=50% and (b) P=70% samples compared to control (solid line)

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Fig. 11

Fabricated cage devices (10mm length indicator)

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Fig. 12

Mechanically tested cages for (a) mean force–displacement and (b) stiffness



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