An approach to designing products based on adapting patterns and behaviors from origami is presented. The approach is illustrated by showing its capability for developing mechanism applications for aerospace-based systems. Origami has several attributes that are sought after in aerospace designs, such as deployability, stowability, and portability. The origami-adapted design process seeks to facilitate designers in reliably adapting origami into useful products that achieve desirable attributes. The origami-adapted design process is illustrated and tested using three examples of preliminary design: an origami bellows to protect the drill shafts of a Mars Rover, an expandable habitat for the International Space Station, and a deployable parabolic antenna for space and earth communication systems. Each of these examples starts with an origami fold pattern and modifies it to fulfill specific needs for an aerospace-based product.