Conventional reliability-based design optimization (RBDO) uses the mean of input random variable as its design variable; and the standard deviation (STD) of the random variable is a fixed constant. However, the constant STD may not correctly represent certain RBDO problems well, especially when a specified tolerance of the input random variable is present as a percentage of the mean value. For this kind of design problem, the STD of the input random variable should vary as the corresponding design variable changes. In this paper, a method to calculate the design sensitivity of the probability of failure for RBDO with varying STD is developed. For sampling-based RBDO, which uses Monte Carlo simulation (MCS) for reliability analysis, the design sensitivity of the probability of failure is derived using a first-order score function. The score function contains the effect of the change in the STD in addition to the change in the mean. As copulas are used for the design sensitivity, correlated input random variables also can be used for RBDO with varying STD. Moreover, the design sensitivity can be calculated efficiently during the evaluation of the probability of failure. Using a mathematical example, the accuracy and efficiency of the developed design sensitivity method are verified. The RBDO result for mathematical and physical problems indicates that the developed method provides accurate design sensitivity in the optimization process.